The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets.

@article{Wen2004TheEO,
  title={The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets.},
  author={Li Wen and Jian Peng and Zhenjun Li and Florence S Wong},
  journal={Journal of immunology},
  year={2004},
  volume={172 5},
  pages={3173-80}
}
Viral infections have previously been implicated as a trigger of autoimmune diabetes. In this study, we compared a viral mimic with other microbial components derived from bacteria in triggering diabetes development in C57BL/6-rat insulin promoter-B7.1 mice that do not normally develop diabetes. It is striking that only the viral mimic induced the development of diabetes in our model system. Further mechanistic studies suggest that diabetes is induced, in part, by the combination of direct… CONTINUE READING

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