The effect of inhibitors of glycosylation on interferon production in human lymphoblastoid cells.

  title={The effect of inhibitors of glycosylation on interferon production in human lymphoblastoid cells.},
  author={B Cundliffe and John Morser},
  journal={The Journal of general virology},
  volume={43 2},
Interferon production was inhibited in the Namalwa line of human lymphoblastoid cells by treatment with 2-deoxy-D-glucose or D-glucosamine. D-Glucosamine also inhibited protein synthesis and the cells were no longer viable, whereas 2-deoxy-D-glucose allowed protein and RNA synthesis to continue at control rates, and the cells remained fully viable. It is concluded that a glycosylation step is essential for production of lymphoblastoid interferon. 
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