The effect of inhibition of angiogenesis in granulation tissue on wound healing and the fibroblast.

@article{McGrath1985TheEO,
  title={The effect of inhibition of angiogenesis in granulation tissue on wound healing and the fibroblast.},
  author={Mary H McGrath and Jeff Emery},
  journal={Annals of plastic surgery},
  year={1985},
  volume={15 2},
  pages={105-22}
}
Protamine sulfate given in high doses can inhibit angiogenesis in the granulation tissue generated in an open wound. This is reflected by changes consistent with delayed vascular maturation in the morphology of the regenerating vessels seen at the gross, microscopic, and ultrastructural levels. A coincidental delay in wound healing as evidenced by impaired wound contraction occurs, although fibroblast duplication and myofibroblast differentiation appear intact. However, the fibroblasts contain… CONTINUE READING