The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation.

Abstract

Intracranial implants elicit neurodegeneration via the foreign body response (FBR) that includes BBB leakage, macrophage/microglia accumulation, and reactive astrogliosis, in addition to neuronal degradation that limit their useful lifespan. Previously, monocyte chemoattractant protein 1 (MCP-1, also CCL2), which plays an important role in monocyte… (More)
DOI: 10.1016/j.biomaterials.2014.05.008

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