The effect of inflammation on the disposition of phenylbutazone in thoroughbred horses.

@article{Mills1996TheEO,
  title={The effect of inflammation on the disposition of phenylbutazone in thoroughbred horses.},
  author={Paul C. Mills and Jack C. Ng and David E. Auer},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={1996},
  volume={19 6},
  pages={
          475-81
        }
}
The effect of inflammation on the disposition of phenylbutazone (PBZ) was investigated in Thoroughbred horses. An initial study (n = 5) in which PBZ (8.8 mg/kg) was injected intravenously twice, 5 weeks apart, suggested that the administration of PBZ would not affect the plasma kinetics of a subsequent dose. Two other groups of horses were given PBZ at either 8.8 mg/kg (n = 5) or 4.4 mg/kg (n = 4). Soft tissue inflammation was then induced by the injection of Freud's adjuvant and the… CONTINUE READING

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