The effect of inducers and inhibitors of urethane metabolism on its in vitro and in vivo metabolism in rats.

@article{Carlson1994TheEO,
  title={The effect of inducers and inhibitors of urethane metabolism on its in vitro and in vivo metabolism in rats.},
  author={Gary P. Carlson},
  journal={Cancer letters},
  year={1994},
  volume={87 2},
  pages={145-50}
}
The activation of urethane (ethyl carbamate) is important in its exerting its carcinogenic effect. Rats were treated with inducers and inhibitors of urethane metabolism, and the conversion of [carbonyl-14C]urethane to 14CO2 in vivo was measured. The cytochrome P-450 inducers, phenobarbital and beta-naphthoflavone, and esterase inhibitor, paraoxon, were… CONTINUE READING