The effect of increasing age on thiopental disposition and anesthetic requirement.

@article{Homer1985TheEO,
  title={The effect of increasing age on thiopental disposition and anesthetic requirement.},
  author={Terri D. Homer and Donald R. Stanski},
  journal={Anesthesiology},
  year={1985},
  volume={62 6},
  pages={714-24}
}
The dose of thiopental required to induce anesthesia in adults decreases with age. The pharmacokinetic and pharmacodynamic properties of thiopental were studied in two groups of surgical patients to determine the mechanism of this decrease. In one group (29 patients 19-88 yr of age), thiopental was infused at a rate of 75-150 mg/min until the electroencephalogram (EEG) demonstrated early burst suppression (phase III). Arterial blood samples were obtained frequently during and after the infusion… CONTINUE READING
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