The effect of increased hepatic sitosterol on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol 7 alpha-hydroxylase in the rat and sitosterolemic homozygotes.

@article{Shefer1994TheEO,
  title={The effect of increased hepatic sitosterol on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol 7 alpha-hydroxylase in the rat and sitosterolemic homozygotes.},
  author={Sarah Shefer and Gerald Salen and J. C. Bullock and L. B. Nguyen and Gene C. Ness and Z Vhao and Peter Francis Belamarich and I R Chowdhary and Steven L. Lerner and AshokK. Batta},
  journal={Hepatology},
  year={1994},
  volume={20 1 Pt 1},
  pages={
          213-9
        }
}
We investigated hepatic cholesterol homeostasis in four homozygous sitosterolemic subjects from two unrelated families who showed enhanced absorption, diminished removal and increased tissue and plasma concentrations of sitosterol (24-ethyl cholesterol). Measurements of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activities were correlated with steady state messenger RNA levels and related to cholesterol 7 alpha-hydroxylase activities in the sitosterolemic homozygotes and nine… CONTINUE READING
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