The effect of incorporating fat into different components of a meal on gastric emptying and postprandial blood glucose and insulin responses.

  title={The effect of incorporating fat into different components of a meal on gastric emptying and postprandial blood glucose and insulin responses.},
  author={K. M. Cunningham and N. Read},
  journal={The British journal of nutrition},
  volume={61 2},
1. Three studies were carried out in each of six normal volunteers to investigate how lipid, when given at different stages during the course of a meal, affects gastric emptying and postprandial blood glucose and insulin concentrations. 2. The control meal consisted of 300 ml beef consommé (50 kJ, 12 kcal), followed 20 min later by 300 g mashed potato (908 kJ, 217 kcal). In the two test meals, 60 g margarine were incorporated into either the soup or the mashed potato. 3. The addition of… Expand
Effects of fat on gastric emptying of and the glycemic, insulin, and incretin responses to a carbohydrate meal in type 2 diabetes.
Ingestion of fat before a carbohydrate meal markedly slows GE and attenuates the postprandial rises in glucose, insulin, and GIP, but stimulates GLP-1, in type 2 diabetes. Expand
Reducing dietary fat from a meal increases the bioavailability of exogenous carbohydrate without altering plasma glucose concentration.
It is suggested that removing fat from the diet expedited exogenous glucose delivery into the systemic circulation and reduced the concentration of key gastrointestinal peptides, yet maintained plasma glucose concentration at control levels. Expand
Effect of nutrient composition in a mixed meal on the postprandial glycemic response in healthy people: a preliminary study
The mixed meal containing three macronutrients (RESO) decreased the PPGR in healthy individuals, leading to significantly lower actual GI and GL values than those derived by nutrient-based calculations. Expand
Effect of lipase inhibition on gastric emptying of, and the glycemic and incretin responses to, an oil/aqueous drink in type 2 diabetes mellitus.
In conclusion, inhibition of fat digestion, by orlistat, may exacerbate postprandial glycemia, as a result of more rapid gastric emptying and a diminished incretin response. Expand
How the degree of unsaturation of dietary fatty acids influences the glucose and insulin responses to different carbohydrates in mixed meals.
The degree of dietary fatty acid unsaturation (18:1 compared with 18:2) may influence the glucose and insulin responses to mixed meals and was significantly lower with dietary PUFA compared with dietary MUFA. Expand
Glycaemic Responses in Type 2 Diabetic Patients to Various Mixed Meals Taken at Home
Eight Type 2 diabetic patients ate and prepared five different meals at home, taking each meal on two separate occasions and postprandial glycaemic responses were significantly greater in the meal with a high ratio of carbohydrate to fat, high in fibre and low in energy. Expand
Influence of dietary fat on postprandial glucose metabolism (exogenous and endogenous) using intrinsically (13)C-enriched durum wheat.
The addition of a large amount of fat appears to be unfavourable to glucose metabolism because it leads to a feature of insulin resistance, and the MF meal did not have these adverse effects, but it was able to decrease the initial glycaemic peak. Expand
Intragastric Lysine Lowers the Circulating Glucose and Insulin Responses to a Mixed-Nutrient Drink without Slowing Gastric Emptying in Healthy Adults.
In healthy adults, lysine slightly reduced the glycemic response to an oral mixed-macronutrient drink, an effect that was apparently independent of insulin or slowing of gastric emptying. Expand
Short-term effects of a moderate fish oil or soybean oil supplementation on postprandial glucose and insulin responses in healthy horses.
To avoid high postprandial glycaemic and insulinaemic responses feeding strategies should be designed primarily to reduce starch intake rather than the addition of fat. Expand
The influence of adding fats of varying saturation on the glycaemic response of white bread
The results of the present study suggest that the glycaemic response of bread can be lowered using any type of fat; therefore, the use of unsaturated fat is recommended for its potential lipidaemic advantage. Expand


Duodenal and ileal lipid suppresses postprandial blood glucose and insulin responses in man: possible implications for the dietary management of diabetes mellitus.
Intestinal lipid can modify the glycaemic and insulinaemic responses to a meal, and this modulation probably explains the reduced metabolic responses toA meal containing fat compared with a fat free meal. Expand
Parallel gastric emptying of nonhydrolyzable fat and water after a solid-liquid meal in humans.
The results imply that gastric emptying of the oil phase is controlled by receptors sensitive to the hydrolytic products of fat digestion and that the slow empties of dietary fat is not simply due to its lower density. Expand
Relationship of the motor activity of the antrum, pylorus, and duodenum to gastric emptying of a solid-liquid mixed meal.
The postprandial motor activity of the antrum, pylorus, and duodenum in 15 healthy volunteers was compared with the profiles of emptying of the solid and liquid components of a meal and the onset of solid emptying was associated with an increase in the rate of occurrence of antral pressure waves. Expand
Relation between antral motility and gastric emptying of solids and liquids in humans.
These human data are consistent with a role of antral pressure activity in trituration of solid food and arole of the antrum in the subsequent propulsion of solids and liquids from the stomach. Expand