The effect of including C-reactive protein in cardiovascular risk prediction models for women.

@article{Cook2006TheEO,
  title={The effect of including C-reactive protein in cardiovascular risk prediction models for women.},
  author={Nancy R. Cook and Julie E. Buring and Paul M. Ridker},
  journal={Annals of internal medicine},
  year={2006},
  volume={145 1},
  pages={
          21-9
        }
}
Context The value of adding high-sensitivity C-reactive protein (hsCRP) to a global risk assessment model is unknown. Contribution The authors used the Women's Health Study, a nationwide cohort of 15048 initially healthy women, to develop a cardiovascular disease (CVD) risk prediction model using hsCRP and Framingham risk model predictors. While hsCRP improved overall model fit, the clinical utility of hsCRP in terms of reclassification was most substantial for those with a 5% or greater 10… CONTINUE READING
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