The effect of inbreeding on early childhood mortality: Twelve generations of an amish settlement

@article{Dorsten2011TheEO,
  title={The effect of inbreeding on early childhood mortality: Twelve generations of an amish settlement},
  author={Linda Eberst Dorsten and Lawrence Hotchkiss and Terri M. King},
  journal={Demography},
  year={2011},
  volume={36},
  pages={263-271}
}
An unresolved issue in research on child survival is the extent to which familial mortality risk in infancy is due to biological influences net of sociodemographic and economic factors. We examine the effect of consanguinity on early childhood mortality in an Old Order Amish settlement by using the inbreeding coefficient, an explicit measure of the degree of relatedness in one’s ancestry. Inbreeding has a net positive effect on neonatal and postneonatal deaths. We find social, demographic, and… 

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References

SHOWING 1-10 OF 48 REFERENCES

Risk factors for infant mortality in nineteenth-century Sweden.

TLDR
Exploratory and multivariate logistic regression analyses reveal an important intra-familial dimension to infant mortality that appears from the early stages of a woman's reproductive career and siblings' shared probabilities of dying as infants suggest that high-birth-order children were not necessarily disadvantaged in any systematic way.

Siblings’ neonatal mortality risks and birth spacing in Bangladesh

TLDR
Findings show that familial association is strongest for siblings of adjacent birth orders, and birth-spacing effects on neonatal mortality are stronger when the preceding child has survived the neonatal period than when it has died.

Birth interval and family effects on postneonatal mortality in Brazil

In this paper random-effects logistic models are used to analyze the effects of the preceding birth interval on postneonatal mortality in Brazil, controlling for the correlation of survival outcomes

Variations in familial neonatal mortality risks in four countries

TLDR
The results suggest that the strength of familial association in neonatal mortality risks is quite similar in these four populations which would be consistent with a biological explanation for the association, however, some differences were found, particularly in the form of the association in Peru, which may suggest at least a small role of other factors.

Consanguineous marriage in South Asia: Incidence, causes and effects

TLDR
Past, present and future trends in population mixing are evaluated, with special consideration of their effects on the health of minority populations living in developed and less developed countries.

Inbreeding and prereproductive mortality in the Old Order Amish. III. Direct and indirect effects of inbreeding.

TLDR
The log-linear model provides a useful approach to the analysis of direct and indirect risk factors using biologic mechanisms and suggests that inbreeding increases the risk of prereproductive mortality by increasing therisk of intrauterine growth retardation and congenital malformations but not prematurity.

Inbreeding and prereproductive mortality in the Old Order Amish. I. Genealogic epidemiology of inbreeding.

Epidemiologic patterns of inbreeding in the Old Order Amish were investigated using a unique genealogic registry of Lancaster County, Pennsylvania, Amish that contains information on 8,163 marriages,

Consanguineous marriage in Turkey and its impact on fertility and mortality

TLDR
According to the results of the study, first cousin marriage is a significant determinant underlying the high total fertility and infant mortality rates in Turkey.

Use of sibling data to estimate family mortality effects in Guatemala.

TLDR
The potential bias in estimates of child mortality determinants produced by the questionable assumption that sibling data are independent is examined, and the unmeasured familial effects shared among siblings are estimated.

Inbreeding and prereproductive mortality in the Old Order Amish. II. Genealogic epidemiology of prereproductive mortality.

TLDR
It could be shown that inbreeding accounts for about 40% of all prereproductive deaths in the present population of the Lancaster County, Pennsylvania, Old Order Amish.