The effect of inbreeding on early childhood mortality: Twelve generations of an amish settlement

  title={The effect of inbreeding on early childhood mortality: Twelve generations of an amish settlement},
  author={Linda Eberst Dorsten and Lawrence Hotchkiss and Terri M. King},
An unresolved issue in research on child survival is the extent to which familial mortality risk in infancy is due to biological influences net of sociodemographic and economic factors. We examine the effect of consanguinity on early childhood mortality in an Old Order Amish settlement by using the inbreeding coefficient, an explicit measure of the degree of relatedness in one’s ancestry. Inbreeding has a net positive effect on neonatal and postneonatal deaths. We find social, demographic, and… 

Tables from this paper

The Effect of Consanguinity on Neonatal Outcomes and Health

The effect of consanguinity on selected gestational outcomes is discussed by delineating the different studies that have led to such findings and the different conclusions that have emerged.

Is Consanguinity an Impediment to Child Development Outcomes?

Marriages between blood relatives – also known as consanguineous unions – are widespread in North Africa, Central and West Asia and most parts of South Asia. Researchers have suggested that

Is consanguinity an impediment to child development?

Assessing the extent to which consanguinity is linked to children’s cognitive and physical development in rural Pakistan finds that impacts on child development are substantial, and likely to be larger than suggested in previous studies.

In-hospital neonatal mortality and the role of consanguinity.

This association of consanguinity with in-hospital mortality points to potential genetic factors leading to this increased risk of infant mortality in newborns.

Consanguinity in Context

An essential guide to this major contemporary issue, Consanguinity in Context is a uniquely comprehensive account of intra-familial marriage. Detailed information on past and present religious,

Consanguinity and reproductive wastage in the Palestinian Territories.

Data from a population-based survey conducted in 2004 in the Palestinian Territories was used and consanguinity was found to be a significant risk factor for reproductive wastage.

An Empirical Analysis of the Effects of Consanguineous Marriages on Economic Development

It is shown that the countries that have reached high average development within the context of per capita GDP have overcome problems integral to consanguineous marriage.

The Role of Consanguineous Marriage on the Success of Asia and the Failure of Africa: Panel Neural Network Analysis

In our study, development experiences towards economic development are investigated to provide an alternative analysis of economic development, human capital and genetic inheritance in light of

Increased homozygosity due to endogamy results in fitness consequences in a human population

The data suggest a multi-locus genetic effect on fitness driven by the expression of deleterious recessive alleles, especially those in long ROH, which is not the result of consanguinity but rather elevated background identity by descent.



Risk factors for infant mortality in nineteenth-century Sweden.

Exploratory and multivariate logistic regression analyses reveal an important intra-familial dimension to infant mortality that appears from the early stages of a woman's reproductive career and siblings' shared probabilities of dying as infants suggest that high-birth-order children were not necessarily disadvantaged in any systematic way.

Siblings’ neonatal mortality risks and birth spacing in Bangladesh

Findings show that familial association is strongest for siblings of adjacent birth orders, and birth-spacing effects on neonatal mortality are stronger when the preceding child has survived the neonatal period than when it has died.

Birth interval and family effects on postneonatal mortality in Brazil

In this paper random-effects logistic models are used to analyze the effects of the preceding birth interval on postneonatal mortality in Brazil, controlling for the correlation of survival outcomes

Variations in familial neonatal mortality risks in four countries

The results suggest that the strength of familial association in neonatal mortality risks is quite similar in these four populations which would be consistent with a biological explanation for the association, however, some differences were found, particularly in the form of the association in Peru, which may suggest at least a small role of other factors.

Consanguineous marriage in South Asia: Incidence, causes and effects

Past, present and future trends in population mixing are evaluated, with special consideration of their effects on the health of minority populations living in developed and less developed countries.

Inbreeding and prereproductive mortality in the Old Order Amish. III. Direct and indirect effects of inbreeding.

The log-linear model provides a useful approach to the analysis of direct and indirect risk factors using biologic mechanisms and suggests that inbreeding increases the risk of prereproductive mortality by increasing therisk of intrauterine growth retardation and congenital malformations but not prematurity.

Inbreeding and prereproductive mortality in the Old Order Amish. I. Genealogic epidemiology of inbreeding.

Epidemiologic patterns of inbreeding in the Old Order Amish were investigated using a unique genealogic registry of Lancaster County, Pennsylvania, Amish that contains information on 8,163 marriages,

Consanguineous marriage in Turkey and its impact on fertility and mortality

According to the results of the study, first cousin marriage is a significant determinant underlying the high total fertility and infant mortality rates in Turkey.

Use of sibling data to estimate family mortality effects in Guatemala.

The potential bias in estimates of child mortality determinants produced by the questionable assumption that sibling data are independent is examined, and the unmeasured familial effects shared among siblings are estimated.

Inbreeding and prereproductive mortality in the Old Order Amish. II. Genealogic epidemiology of prereproductive mortality.

It could be shown that inbreeding accounts for about 40% of all prereproductive deaths in the present population of the Lancaster County, Pennsylvania, Old Order Amish.