The effect of in utero exposure to hexachlorobenzene on the developing immune response of BALB/c mice.

@article{Barnett1987TheEO,
  title={The effect of in utero exposure to hexachlorobenzene on the developing immune response of BALB/c mice.},
  author={John B Barnett and L. J. Barfield and Ron Walls and Raymond Joyner and Rebecca Owens and L. S. F. Soderberg},
  journal={Toxicology letters},
  year={1987},
  volume={39 2-3},
  pages={263-74}
}
BALB/c mice were exposed to 0.0, 0.5 and 5.0 mg/kg maternal body weight hexachlorobenzene (HCB) throughout gestation by daily per os dosing of the females. At 45 days of age selected immune functions of the offspring were assessed. The delayed-type hypersensitivity (DTH) response to oxazolone was severely depressed in animals exposed to either 0.5 or 5.0 mg/kg HCB, however, only those animals exposed to 5.0 mg/kg HCB showed a significant decrease in their mixed lymphocyte response (MLR) levels… CONTINUE READING

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