The effect of immunosuppressive molecules on T-cell metabolic reprogramming.

@article{FernndezRamos2016TheEO,
  title={The effect of immunosuppressive molecules on T-cell metabolic reprogramming.},
  author={Ana A Fern{\'a}ndez-Ramos and Virginie Poindessous and Catherine Marchetti-Laurent and Nicolas Pietrancosta and Marie-Anne Loriot},
  journal={Biochimie},
  year={2016},
  volume={127},
  pages={23-36}
}
T lymphocytes undergo metabolic reprogramming to adapt to extracellular and intracellular cues. Specifically, T-cell metabolism results into ATP production, anabolism and catabolism pathways that not only support rapid cell growth and proliferation, but also differentiation and effector functions, recently referred as "immunometabolism". Quiescent naïve T cells rely on oxidative phosphorylation whereas aerobic glycolysis (Warburg effect) occurs in activated T cells (effector CD4(+) and CD8… CONTINUE READING