The effect of immobilized RGD peptide in alginate scaffolds on cardiac tissue engineering.

@article{Shachar2011TheEO,
  title={The effect of immobilized RGD peptide in alginate scaffolds on cardiac tissue engineering.},
  author={Michal Shachar and Orna Tsur-Gang and Tal Dvir and Jonathan Leor and Smadar Cohen},
  journal={Acta biomaterialia},
  year={2011},
  volume={7 1},
  pages={152-62}
}
Cardiac tissue engineering aims to regenerate damaged myocardial tissues by applying heart patches created in vitro. The present study was undertaken to explore the possible role of matrix-attached RGD peptide in the engineering of cardiac tissue within macroporous scaffolds. Neonatal rat cardiac cells were seeded into RGD-immobilized or unmodified alginate scaffolds. The immobilized RGD peptide promoted cell adherence to the matrix, prevented cell apoptosis and accelerated cardiac tissue… CONTINUE READING