The effect of immobilization on collagen turnover in connective tissue: a biochemical-biomechanical correlation.

@article{Amiel1982TheEO,
  title={The effect of immobilization on collagen turnover in connective tissue: a biochemical-biomechanical correlation.},
  author={David Amiel and Savio L-Y Woo and Frederick L Harwood and Wayne H. Akeson},
  journal={Acta orthopaedica Scandinavica},
  year={1982},
  volume={53 3},
  pages={325-32}
}
Immobilization of the knee joint for 9 weeks results in a reduction of the mechanical properties in the lateral collateral ligament. Specifically, ligament stiffness is reduced in this tissue. No statistical change in collagen mass was detected for the medial collateral ligament (MCL) or patellar tendon. An increase in collagen turnover (synthesis and degradation) was, however, found in the immobilized medial collateral ligament and patellar tendon. It is thus proposed that stiffness reduction… CONTINUE READING

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