The effect of hypothalamic paraventricular nuclear lesions placed at 108-110 days gestational age on plasma ACTH concentrations in the fetal sheep.

Abstract

Lesions that completely destroyed the paraventricular nucleus of the hypothalamus were placed in fetal sheep (n = 4) at 108-110 days of gestational age. These fetuses were then subjected to hypotension (50% of initial mean fetal arterial blood pressure), hypoxaemia (a decrease in fetal PaO2 greater than or equal to 5 torr) and bolus injection of… (More)

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@article{McDonald1988TheEO, title={The effect of hypothalamic paraventricular nuclear lesions placed at 108-110 days gestational age on plasma ACTH concentrations in the fetal sheep.}, author={Thomas J. McDonald and J Cameron Rose and Jorge P. Figueroa and Peter D. Gluckman and Peter Nathanielsz}, journal={Journal of developmental physiology}, year={1988}, volume={10 3}, pages={191-200} }