The effect of hypocretin replacement therapy in a 3-year-old Weimaraner with narcolepsy.

@article{Schatzberg2004TheEO,
  title={The effect of hypocretin replacement therapy in a 3-year-old Weimaraner with narcolepsy.},
  author={Scott J. Schatzberg and K Cutter-Schatzberg and Daryl V. Nydam and Jennifer Barrett and Richard Penn and James A. Flanders and Alexander Delahunta and Ling Lin and Emmanuel Mignot},
  journal={Journal of veterinary internal medicine},
  year={2004},
  volume={18 4},
  pages={
          586-8
        }
}
Both the number ofattacks (NA) and elapsed time in collapse (ET) were mea-sured as an index of cataplexy severity. Further supportingthe diagnosis of narcolepsy and cataplexy, we measured adramatic response to IV yohimbine (Figs 1, 2; NA and ETwith no treatment: median, 6 collapses and 50.5 seconds,respectively; NA and ET with 0.048 mg/kg IV: median, 0.5collapses [P 5 .004] and 9.5 seconds [P 5 .005, Wilcoxonrank sum test], respectively).