The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure

@article{Murphy2004TheEO,
  title={The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure},
  author={N. Murphy and G. Auzinger and W. Bernel and J. Wendon},
  journal={Hepatology},
  year={2004},
  volume={39}
}
  • N. Murphy, G. Auzinger, +1 author J. Wendon
  • Published 2004
  • Medicine
  • Hepatology
  • Acute liver failure (ALF) is a rare condition characterized by the development of encephalopathy in the absence of chronic liver disease. Cerebral edema occurs in up to 80% of patients with Grade IV encephalopathy. In the current prospective randomized controlled clinical trial, we examined the effect of induced hypernatremia on the incidence of intracranial hypertension (IH) in patients with ALF. Thirty patients with ALF and Grade III or IV encephalopathy were randomized. Patients in Group 1… CONTINUE READING
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    References

    SHOWING 1-10 OF 41 REFERENCES
    Treatment of hyponatraemic seizures with intravenous 29.2% saline.
    • 86
    • PDF