The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure

@article{Murphy2004TheEO,
  title={The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure},
  author={N. Murphy and G. Auzinger and W. Bernel and J. Wendon},
  journal={Hepatology},
  year={2004},
  volume={39}
}
  • N. Murphy, G. Auzinger, +1 author J. Wendon
  • Published 2004
  • Medicine
  • Hepatology
    • Acute liver failure (ALF) is a rare condition characterized by the development of encephalopathy in the absence of chronic liver disease. Cerebral edema occurs in up to 80% of patients with Grade IV encephalopathy. In the current prospective randomized controlled clinical trial, we examined the effect of induced hypernatremia on the incidence of intracranial hypertension (IH) in patients with ALF. Thirty patients with ALF and Grade III or IV encephalopathy were randomized. Patients in Group 1… CONTINUE READING
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    References

    SHOWING 1-10 OF 41 REFERENCES
    Use of hypertonic saline in the treatment of severe refractory posttraumatic intracranial hypertension in pediatric traumatic brain injury
    • 320
    • PDF
    Subclinical Seizure Activity and Prophylactic Phenytoin Infusion in Acute Liver Failure: A Controlled Clinical Trial
    • 125
    Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failure.
    • 252
    • PDF
    Dissociated cerebral vasoparalysis in acute liver failure. A hypothesis of gradual cerebral hyperaemia.
    • 89
    The safety and value of extradural intracranial pressure monitors in fulminant hepatic failure.
    • 92
    Cerebral herniation in patients with acute E liver failure is correlated with arterial ammonia concentration
    • 559
    Cerebral blood flow and metabolism in fulminant liver failure
    • 202
    Treatment of hyponatraemic seizures with intravenous 29.2% saline.
    • 86
    • PDF
    Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension
    • 316
    Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis.
    • 113