The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure

@article{Murphy2004TheEO,
  title={The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure},
  author={Nicholas Murphy and Georg Auzinger and William Bernel and Julia A. Wendon},
  journal={Hepatology},
  year={2004},
  volume={39}
}
Acute liver failure (ALF) is a rare condition characterized by the development of encephalopathy in the absence of chronic liver disease. Cerebral edema occurs in up to 80% of patients with Grade IV encephalopathy. In the current prospective randomized controlled clinical trial, we examined the effect of induced hypernatremia on the incidence of intracranial hypertension (IH) in patients with ALF. Thirty patients with ALF and Grade III or IV encephalopathy were randomized. Patients in Group 1… 
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Acute liver failure: current management and future prospects.
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Although an ample body of experimental and human data provides a rationale for the use of therapeutic Hypothermia in patients with acute liver failure, multicenter, randomized, controlled clinical trials are needed to confirm that hypothermia secures brain viability and improves survival without causing harm.
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