The effect of hypertonic (3%) saline with and without furosemide on plasma osmolality, sodium concentration, and brain water content after closed head trauma in rats.

@article{Mayzler2006TheEO,
  title={The effect of hypertonic (3%) saline with and without furosemide on plasma osmolality, sodium concentration, and brain water content after closed head trauma in rats.},
  author={Olga Mayzler and Avner Leon and Israel Eilig and Yulia Fuxman and Moni Benifla and Paulo Cesar Freixo and B. M. Gurevich and Ravit Agassi and Alan A. Artru and Yoram Shapria},
  journal={Journal of neurosurgical anesthesiology},
  year={2006},
  volume={18 1},
  pages={24-31}
}
Adding furosemide (F) to mannitol causes a greater decrease of brain volume, intracranial pressure, and brain water content (BW) as compared with mannitol alone. We examined whether adding F to hypertonic saline (HS) causes less increase of BW early after closed head trauma (CHT) as compared with HS alone. With institutional approval, 125 rats underwent sham surgery or CHT and then immediately received no treatment, HS (1.2 g/kg, 3% solution), or HS + F (2 mg/kg). In groups 1-10 (n = 8/group… CONTINUE READING

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