The effect of hydrophobicity upon the direct mutagenicity of N-acyloxy-N-alkoxyamides--Bilinear dependence upon LogP.

@article{Glover2016TheEO,
  title={The effect of hydrophobicity upon the direct mutagenicity of N-acyloxy-N-alkoxyamides--Bilinear dependence upon LogP.},
  author={Stephen A. Glover and Rhiannon R Schumacher},
  journal={Mutation research. Genetic toxicology and environmental mutagenesis},
  year={2016},
  volume={795},
  pages={41-50}
}
N-Acyloxy-N-alkoxyamides 1 are direct-acting mutagens for which a bilinear QSAR has been established, which predicts with accuracy their activity in the Ames reverse mutation assay in Salmonella typhimurium TA100, based upon their hydrophobicity (LogP), reactivity (pKA of the carboxylic acid of the N-carboxyl group) and TAFT steric parameters. From activity… CONTINUE READING