The effect of human eosinophil granule major basic protein on airway responsiveness in the rat in vivo. A comparison with polycations.

Abstract

Major basic protein (MBP) is a highly cationic protein found in the granules of eosinophils. It has been postulated that MBP may participate in the pathogenesis of airway hyperresponsiveness exhibited by asthmatic patients. Accordingly, we used a rat model to investigate the effect of human MBP instillation on airway responsiveness and the possible role of… (More)

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@article{Uchida1993TheEO, title={The effect of human eosinophil granule major basic protein on airway responsiveness in the rat in vivo. A comparison with polycations.}, author={Derek A Uchida and S J Ackerman and Andrew J. Coyle and Gary L. Larsen and Peter Weller and James Freed and Charles G. Irvin}, journal={The American review of respiratory disease}, year={1993}, volume={147 4}, pages={982-8} }