The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents.

BACKGROUND Hyperkalemia is a potentially life-threatening disorder frequently occurring in hospitalized patients. The ischemic myocardium releases potassium into the extracellular space which can cause regional hyperkalemia. These changes may modify the effects of anti-arrhythmic drugs acting on the rapid component of the delayed rectifier potassium current… CONTINUE READING