The effect of high concentration of magnesium with ropivacaine, gentamicin, rocuronium, and their combination on neuromuscular blockade

  title={The effect of high concentration of magnesium with ropivacaine, gentamicin, rocuronium, and their combination on neuromuscular blockade},
  author={Won Ji Rhee and Seung Yoon Lee and J. H. Lee and S. Choi and Seung-Cheol Lee and Jong Hwan Lee and Soo-il Lee},
  journal={Korean Journal of Anesthesiology},
  pages={50 - 61}
Background Magnesium, ropivacaine, gentamicin, and rocuronium block neuromuscular (NM) transmission by different mechanisms. Therefore, concurrent administration of these agents may induce prolonged muscle paralysis via synergistic interaction. This study investigated the efficacy and safety of NM block caused by the administration of high concentrations of magnesium in combination with ropivacaine, gentamicin, and rocuronium. Methods Eighty-three left phrenic nerve-hemidiaphragms from male SD… Expand
Effects of magnesium chloride on rocuronium-induced neuromuscular blockade and sugammadex reversal in an isolated rat phrenic nerve–hemidiaphragm preparation: An in-vitro study
Increases in MgCl2 concentration reduce the ECs of rocuronium, and administering sugammadex equimolar to the administered roCuronium shows limited efficacy as Mgcl2 concentration is increased. Expand
The effect of magnesium on the reversal of rocuronium-induced neuromuscular block with sugammadex: an ex vivo laboratory study
Magnesium potentiates the neuromuscular effect of rocuronium and shifts the concentration-response curve to the left and decreases the safety margin of reversal of roCuronium-induced neuromUScular block with sugammadex. Expand
Benefits and risks of sugammadex
Although sugammadex has some benefits, it also has several side effects, and this is an important factor that may limit its use as a routine antagonist of neuromuscular-blocking drugs. Expand
Effect of Withania somnifera on gentamicin induced renal lesions in rats
Withania somnifera as a nephroprotective and nephrocurative molecule significantly restore the renal function on gentamicin-induced nephrotoxicity in wistar rats. Expand
Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021
These evidence-based guidelines provide health care providers with recommended best practices for diagnosing, monitoring, and treating single cases or outbreaks of foodborne, wound, and inhalational botulism and were developed after a multiyear process involving several systematic reviews and expert input. Expand
ffect of Withania somnifera on gentamicin induced renal lesions in ats rem
Gentamicin induced renal complications are well known in humans and animals. Medicinal properties of Withania somnifera (L.) Dunal, Solanaceae, are recognized to improve renal functions. However, theExpand
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Do bupivacaine, clindamycin, and gentamicin at their clinical concentrations enhance rocuronium-induced neuromuscular block?
Bupivacaine, clindamycin, and gentamicin blocked NM conduction, and when all three drugs were applied together, they augmented rocuronium-induced NM block at their near-therapeutic concentrations. Expand
The synergistic effect of gentamicin and clindamycin on rocuronium-induced neuromuscular blockade
It is demonstrated that gentamicin and clindamycin potentiated rocuronium induced neuromuscular blockade and it was found that these drugs interacted synergistically. Expand
At therapeutic concentration bupivacaine causes neuromuscular blockade and enhances rocuronium-induced blockade
Clinicians should be aware that bupivacaine by itself at its therapeutic concentration inhibit NM conduction and enhances rocuronium-induced muscle relaxation. Expand
Administration of magnesium sulphate before rocuronium: effects on speed of onset and duration of neuromuscular block.
Prior administration of magnesium sulphate, under the study conditions described, prolonged rocuronium-induced neuromuscular block but did not increase speed of onset, and was not associated with adverse haemodynamic effects. Expand
Magnesium potentiates neuromuscular blockade with cisatracurium during cardiac surgery
In patients undergoing cardiac surgery, administration of magnesium sulfate, resulting in ionized levels of 1.3 mmol· L−1, results in a 30–35 min prolongation of the neuromuscular blockade induced with intubating and maintenance doses of cisatracurium and does not alter hemodynamic stability. Expand
Interaction of muscle relaxants and local anesthetics at the neuromuscular junction.
Findings suggest that the interaction of NM blocking agents and local anesthetics consists of true potentiation caused by the different sites of action of the two types of compounds at the NM junction. Expand
Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.
The incidence of CNS symptoms and changes in echocardiography and electrophysiology during i.v. infusions of ropivacaine, bupivadaine and placebo are compared and a threshold for CNS toxicity was apparent at a mean free plasma concentration of approximately 0.6 mg litre-1. Expand
Electromyographic and mechanomyographic characteristics of neuromuscular block by magnesium sulphate in the pig.
These characteristics of neuromuscular block by Mg2+ reflect its prejunctional mechanism of action by depression of transmitter release. Expand
Comparative Pharmacokinetics of Bupivacaine and Ropivacaine, a New Amide Local Anesthetic
Results of this pharmacokinetic study indicate that after IV infusion of bupvacaine and ropivacaine, concentrations of rop Vivacaine decrease more rapidly than bupavacaine during the elimination phase, which may result in a greater margin of safety for the new agent. Expand
Clinical Use of Magnesium Infusions in Anesthesia
  • M. James
  • Medicine
  • Anesthesia and analgesia
  • 1992
This review examines some aspects of the pharmacology of hypermagnesemia that may be of relevance in anesthesia and investigates the interactions between this agent and the pharmacologic and physiologic mechanisms of hemodynamic control. Expand