The effect of heterogeneity on optimal regimens in cancer chemotherapy.

  title={The effect of heterogeneity on optimal regimens in cancer chemotherapy.},
  author={John M. Murray and Andrew J. Coldman},
  journal={Mathematical biosciences},
  volume={185 1},
Optimal drug regimens for cancer chemotherapy are determined when knowledge is only available on the behaviour of the tumour and the drugs used, over a population of patients. The case of two drugs is investigated where they are equivalent on average. Our calculations indicate that the optimal regimen has both drugs given initially but then sequences the two drugs. Our calculations also indicate that as tumour heterogeneity increases, the benefit to be gained from the optimal regimen can… CONTINUE READING

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