The effect of heterogeneity in tumor cell kinetics on radiation dose-response. An exploratory investigation of a plateau effect.

@article{Suwiski1999TheEO,
  title={The effect of heterogeneity in tumor cell kinetics on radiation dose-response. An exploratory investigation of a plateau effect.},
  author={Rafal Suwiński and Jeremy M.G. Taylor and Hubert Rodney Withers},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={1999},
  volume={50 1},
  pages={
          57-66
        }
}
PURPOSE To investigate the effect of heterogeneity in tumor cell kinetics on radiation dose-response curves for a population of patients. MATERIALS AND METHODS A series of exploratory calculations have been performed using an improved geometric-stochastic model of tumor cure. RESULTS Radiation therapy dose-response curves may plateau, or nearly so, at tumor control levels well below 100%, if a proportion of tumors would grow sufficiently fast to counterbalance the effect of fractionated… CONTINUE READING