The effect of hepatic cirrhosis on the pharmacokinetics and blood pressure response to nicardipine.

Abstract

The present study was designed to compare the pharmacokinetic handling of a single oral dose of nicardipine in normal subjects and in patients with hepatic cirrhosis and to compare the sensitivity of the two groups to its hypotensive effect. Nicardipine plasma concentrations were substantially higher in the subjects with hepatic cirrhosis with impaired… (More)

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@article{Razak1990TheEO, title={The effect of hepatic cirrhosis on the pharmacokinetics and blood pressure response to nicardipine.}, author={Tasnim Abdul Razak and Jolene McNeil and Richard B Sewell and Olaf Heino Drummer and Rodney Smallwood and Eunice L. Conway and William J. Louis}, journal={Clinical pharmacology and therapeutics}, year={1990}, volume={47 4}, pages={463-9} }