The effect of hemoglobin carbamylation on the survival of human sickle cell erythrocytes in rats.

Abstract

The in vitro incubation of human sickle cell erythrocytes (SS RBCs) with sodium cyanate results in significant prolongation of their 'Cr intravascular survival (1, 2). This effect appears to be mediated through carbamylation of the amino terminal valine residue in the hemoglobin S molecule which results in inhibition of erythrocyte sickling (3). Initial… (More)

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