The effect of halothane on the sarcoplasmic reticulum in normal and right ventricular hypertrophy in rabbits.

Calcium accumulation and storage by the sarcoplasmic reticulum is affected adversely by both inhaled anesthetics and hypertrophy. The interaction of these two conditions in right ventricular muscle was examined in a skinned fiber preparation whereby the sarcolemma was disrupted mechanically to permit external control of the chemical composition of the… (More)