The effect of gut microbiota and probiotic organisms on the properties of extended spectrum beta-lactamase producing and carbapenem resistant Enterobacteriaceae including growth, beta-lactamase activity and gene transmissibility.

  title={The effect of gut microbiota and probiotic organisms on the properties of extended spectrum beta-lactamase producing and carbapenem resistant Enterobacteriaceae including growth, beta-lactamase activity and gene transmissibility.},
  author={Hiroyuki Kunishima and Noriomi Ishibashi and Kaoru Wada and Kentaro Oka and Motomichi Takahashi and Yukitaka Yamasaki and Tetsuji Aoyagi and Hiromu Takemura and Miho Kitagawa and Mitsuo Kaku},
  journal={Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy},
  • H. KunishimaNoriomi Ishibashi M. Kaku
  • Published 6 June 2019
  • Biology, Medicine
  • Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant Enterobacterales

The search for multifunctional probiotics and synbiotics could render the eradication of “bad” Enterobacterales in the human gut via probiotic administration achievable in the future.

Effect of Clostridium butyricum on Gastrointestinal Infections

The effects of C. butyricum, including CBM 588, on bacterial gastrointestinal infections are summarized and it is expected to be one of the antimicrobial-resistance (AMR) countermeasures for the One-health approach.

Prolonged Carriage of Carbapenemase-Producing Enterobacteriaceae: Clinical Risk Factors and the Influence of Carbapenemase and Organism Types

Prolonged carriage of carbapenemase-producing Enterobacteriaceae (CPE) constitutes a substantial epidemiologic threat. This study aimed to evaluate whether the types of carbapenemase and organism can

How Probiotics Affect the Microbiota

The relation between probiotics and the gut and skin microbiota is explored and it is argued that probiotics could be associated with conventional drugs for insulin resistance, infectious diseases, inflammatory diseases, and psychiatric disorders and could also interfere with drug metabolism.

The impacts of probiotics in eradication therapy of Helicobacter pylori

Probiotics may have a beneficial effect on H. pylori eradication, however, the strain, dosages, duration times, and safety of probiotic supplementation need further study before clinical applications.

Gut microbiome and mycobiome in inflammatory bowel disease patients with Clostridioides difficile infection

Gut micro-ecological changes in IBD patients with CDI might provide insight into the pathological process and potential strategies for diagnosis and treatment in this subset of patients.

Rapid Detection of β-Lactamase-Producing Bacteria Using the Integrated Comprehensive Droplet Digital Detection (IC 3D) System

This study demonstrates a promising strategy for the detection of β-lactamase-producing bacteria at single-cell sensitivity using the recently developed IC 3D system.

Liver fat metabolism of broilers regulated by Bacillus amyloliquefaciens TL via stimulating IGF-1 secretion and regulating the IGF signaling pathway

The metabolites of B.A-TL were involved in the insulin/IGF signaling pathway, regulating the expressions of lipid metabolism genes and the FASN protein, ultimately regulating the lipid metabolism via the IGF/PI3K/FASN pathway in broilers.

A Novel Computer-Aid Nanotechnology Targeting to Combat Antibiotics Resistance with Superbugs against COVID-19 Pandemic

  • Hyunjo Kim
  • Biology
    Archives in Biomedical Engineering & Biotechnology
  • 2021
Based on nano-medicine performance, successful experiments, and considerable market prospects, nanotechnology will undoubtedly lead a breakthrough in biomedical field also for infectious diseases, as there are several nanotechnological approaches that exhibit important roles in restoring antibiotic activity against resistant bacteria.



Emergence of Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs) in the community.

A heightened awareness of these organisms by clinicians and enhanced testing by laboratories, including molecular surveillance studies, is required to reduce treatment failures, to limit their introduction into hospitals and to prevent the spread of these emerging pathogens within the community.

Community spread of extended-spectrum β-lactamase-producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis: a long-term study in Japan.

It is believed to be the first report from Japan showing a definite increase in ESBL detection in outpatients and the findings suggest the simultaneous community spread of diverse ESBL genotypes, not an expansion of particular ESBL genes.

Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat

  • P. Bradford
  • Biology, Medicine
    Clinical Microbiology Reviews
  • 2001
β-Lactamases continue to be the leading cause of resistance to β-lactam antibiotics among gram-negative bacteria and are now found in a significant percentage of Escherichia coli and Klebsiella pneumoniae strains in certain countries.

Fecal carriage of CTX-M β-lactamase-producing Enterobacteriaceae in nursing homes in the Kinki region of Japan

Nursing home residents in Japan exhibit a high prevalence of CTX-M-type ESBL-producing Enterobacteriaceae carriage, with a high level of co-resistance to quinolones, according to multivariate logistic regression analysis.

Extended-Spectrum β-Lactamases: a Clinical Update

Extended-spectrum β-lactamases represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents.

Trends in Human Fecal Carriage of Extended-Spectrum β-Lactamases in the Community: Toward the Globalization of CTX-M

It is suggested that CTX-M carriage is evolving toward a global pandemic but is still insufficiently described, and only a better knowledge of its dynamics and biology will lead to further development of appropriate control measures.

Inhibition of the cytotoxic effect of Clostridium difficile in vitro by Clostridium butyricum MIYAIRI 588 strain.

It was found that the toxicity of C. difficile in in vitro co-culture with CBM588 was greatly decreased or absent and that the detoxification probably occurred by the inhibition of toxin protein production and that this required close proximity or contact between the two species.

Influence of intestinal anaerobes and organic acids on the growth of enterohaemorrhagic Escherichia coli O157:H7.

A suspension of human faeces (FS) and its anaerobic culture (FC), bacterial metabolic products and organic acids were examined for inhibitory effects on growth and verotoxin 2 (VT2) production of