The effect of growth/differentiation factor-5 deficiency on femoral composition and mechanical behavior in mice.

@article{Mikic2002TheEO,
  title={The effect of growth/differentiation factor-5 deficiency on femoral composition and mechanical behavior in mice.},
  author={Borjana Mikic and Todd C. Battaglia and E. A. Taylor and R T Clark},
  journal={Bone},
  year={2002},
  volume={30 5},
  pages={
          733-7
        }
}
A subclass of the bone morphogenetic proteins (BMPs), known as growth/differentiation factors (GDFs) 5, 6, and 7, have been shown to affect several skeletal processes, including endochondral ossification, synovial joint formation, and tendon and ligament repair. Mice deficient in GDF-5 have also been shown to exhibit biomechanical abnormalities in tendon that may be associated with altered type I collagen. The purpose of this study was to investigate the effect of GDF-5 deficiency on another… CONTINUE READING

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