The effect of graded hypothermia on hypoxic-ischemic brain damage: a neuropathologic study in the neonatal rat.

@article{Young1983TheEO,
  title={The effect of graded hypothermia on hypoxic-ischemic brain damage: a neuropathologic study in the neonatal rat.},
  author={Richard S K Young and Thomas P. Olenginski and Susan K Yagel and Javad Towfighi},
  journal={Stroke},
  year={1983},
  volume={14 6},
  pages={929-34}
}
To investigate the relationship between neuropathologic damage and cerebral metabolic alterations during hypothermia in the neonatal animal, 7 day old Sprague-Dawley rats were subjected to unilateral common carotid artery ligation and hypoxia at 37 degrees C, 29 degrees C, and 21 degrees C. At 37 degrees C, animals had extensive infarction of tectum and ipsilateral cerebral hemisphere, and marked depletion of brain ATP. At 29 degrees C, there was no significant change in brain ATP… CONTINUE READING

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Hypothermia and stroke: the pathophysiological background.

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