The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock.

@article{Ortolani2000TheEO,
  title={The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock.},
  author={O. Ortolani and A. Conti and A. R. de Gaudio and E. Moraldi and Q. Cantini and G. Novelli},
  journal={American journal of respiratory and critical care medicine},
  year={2000},
  volume={161 6},
  pages={
          1907-11
        }
}
  • O. Ortolani, A. Conti, +3 authors G. Novelli
  • Published 2000
  • Medicine
  • American journal of respiratory and critical care medicine
  • Both the hyperproduction of oxygen free radicals (OFR) and the weakening of natural scavenging mechanisms have been implicated as contributors to multiple organ failure in septic shock. This study examined whether the antioxidants glutathione (GSH) and N-acetyl-L-cysteine (NAC) play a protective role against damage by OFR in early septic shock. We randomly entered 30 patients with septic shock into one of three groups within 24 h of diagnosis. All of the patients received septic shock therapy… CONTINUE READING

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