The effect of gentamicin on acetylsalicylic acid-induced platelet antiaggregatory action in mouse pial arterioles.

Abstract

Gentamicin (G) treatment (5, 20, 40 and 80 mg kg[-1] day[-1] given intramuscularly for 6 days) was shown to cause a dose-related platelet proaggregatory effect in mouse pial microcirculation. This was associated with a reduction in mouse renal function, indicated by high plasma creatinine and urea concentrations. When G was given at the same doses but as a single injection, it caused no change in renal function or platelet aggregation. Gentamicin (20 and 80 mg kg/day, given intramuscularly for 6 days) significantly (P < 0.05) impeded the platelet antiaggregatory effect of acetylsalicylic acid (100 mg kg[-1], intraperitoneally).

Cite this paper

@article{ElSabban1998TheEO, title={The effect of gentamicin on acetylsalicylic acid-induced platelet antiaggregatory action in mouse pial arterioles.}, author={F M El-Sabban and Badreldin H Ali and Ahmad Khan Bashir and Musbah O. M. Tanira}, journal={Life sciences}, year={1998}, volume={62 15}, pages={1361-9} }