The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide

@article{Zouk2007TheEO,
  title={The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide},
  author={Hana Zouk and Alexander McGirr and V{\'e}ronique Lebel and C Benkelfat and Guy A. Rouleau and Gustavo Turecki},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2007},
  volume={144B}
}
  • H. Zouk, A. McGirr, G. Turecki
  • Published 5 December 2007
  • Psychology, Biology
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Impulsive–aggressive behaviors (IABs) are regarded as possible suicide intermediate phenotypes, mediating the relationship between genes and suicide outcome. In this study, we aimed to investigate the putative relationship between genetic variation at the 5‐HT1B receptor gene, which in animal models is involved in impulse‐aggression control, IABs, and suicide risk. We investigated the relationship of variation at five 5‐HT1B loci and IAB measures in a sample of 696 subjects, including 338… 
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