The effect of gene interactions on the long-term response to selection.

@article{Paixo2016TheEO,
  title={The effect of gene interactions on the long-term response to selection.},
  author={Tiago Paix{\~a}o and Nicholas H. Barton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 16},
  pages={
          4422-7
        }
}
The role of gene interactions in the evolutionary process has long been controversial. Although some argue that they are not of importance, because most variation is additive, others claim that their effect in the long term can be substantial. Here, we focus on the long-term effects of genetic interactions under directional selection assuming no mutation or dominance, and that epistasis is symmetrical overall. We ask by how much the mean of a complex trait can be increased by selection and… CONTINUE READING

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