The effect of garlic extract on human metabolism of acetaminophen.

  title={The effect of garlic extract on human metabolism of acetaminophen.},
  author={Peter R. Gwilt and C L Lear and Margaret A. Tempero and D D Birt and Ann C. Grandjean and Raymond W. Ruddon and Dieter Nagel},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={3 2},
Several studies suggest that the constituents of garlic may inhibit experimentally induced carcinogenesis. To evaluate the chemopreventive properties of garlic in humans, the effects of chronic administration of an aged garlic extract on the disposition of acetaminophen and metabolites were studied. This commonly used drug was chosen because it forms a reactive electrophilic metabolite after oxidative metabolism. Sixteen subjects ingested daily doses of garlic extract (approximately equivalent… CONTINUE READING