The effect of gamma radiation on the degradation of salbutamol.

@article{Basly1997TheEO,
  title={The effect of gamma radiation on the degradation of salbutamol.},
  author={J. P. Basly and J. L. Duroux and M. Bernard},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={1997},
  volume={15 8},
  pages={1137-41}
}
The use of ionizing radiation for sterilization of pharmaceuticals is now a well established technology. Degradation of salbutamol was investigated after gamma irradiation using HPLC and ESR spectroscopy. HPLC evidenced the formation of radiolytic products after gamma irradiation. Salbutamol showed a degradation of nearly 2% at 25 kGy. Sterilization of… CONTINUE READING