• Corpus ID: 101601115

The effect of fordine on learning and memory in rats

  title={The effect of fordine on learning and memory in rats},
  author={Chen Sm and Xue Zg},
  journal={Acta pharmaceutica Sinica},
  • Chen Sm, Xue Zg
  • Published 1 November 1987
  • Biology, Chemistry, Medicine
  • Acta pharmaceutica Sinica
Fordine, a new alkaloid, was extracted from Chinese herbs Huperziaceae, including Phlegmariurus fordii (Baker) Ching and Huperzia serrata (Thunb.) Trey. It has been shown to inhibit true cholinesterase activity selectively (LD_(50)=3.0 mg/kg ip, 3.6 mg/kg po in mice) and to have therapeutic effect on experimental animal myasthenia gravis. Fordine at doses of 10,40 μg/kg ip or 20 μg/kg po before training caused rapid formation of active avoidance response and significantly increased the active… 
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Recent advances in pharmacognosy research in China.