The effect of folic acid supplementation on the pharmacokinetics and pharmacodynamics of oral methotrexate during the remission-induction period of treatment for moderate-to-severe plaque psoriasis

@article{Chldek2007TheEO,
  title={The effect of folic acid supplementation on the pharmacokinetics and pharmacodynamics of oral methotrexate during the remission-induction period of treatment for moderate-to-severe plaque psoriasis},
  author={Jaroslav Chl{\'a}dek and Marie {\vS}imkov{\'a} and Jaroslava Vaně{\vc}kov{\'a} and Milo{\vs} Hroch and Jirina Chl{\'a}dkov{\'a} and Jiřina Mart{\'i}nkov{\'a} and Jaroslava V{\'a}vrov{\'a} and Martin Ber{\'a}nek},
  journal={European Journal of Clinical Pharmacology},
  year={2007},
  volume={64},
  pages={347-355}
}
We assessed the effect of folic acid (FA) on the pharmacokinetics and pharmacodynamics of low-dose oral methotrexate (MTX) during the remission-induction phase of psoriasis treatment. In a 32-week, open-label, two-way cross-over study, patients (n = 20, seven men, aged 35–70 years) with moderate-to-severe plaque psoriasis were randomly assigned to receive MTX plus FA (20 mg/week) for 16 weeks followed by MTX monotherapy (three doses of MTX separated by 12-h intervals once a week) for an… CONTINUE READING
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