The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinate.

@article{Ma2006TheEO,
  title={The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinate.},
  author={Li-wei Ma and Arnfinn Engeset Steindal and Asta Juzeniene and Vladimir Iani and Johan Emelian Moan},
  journal={Photochemical \& photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology},
  year={2006},
  volume={5 8},
  pages={
          755-9
        }
}
  • Li-wei Ma, A. E. Steindal, +2 authors J. Moan
  • Published 2006
  • Chemistry, Medicine
  • Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
5-Aminolevulinic acid (ALA) or its derivative methyl 5-aminolevulinate (MAL) combined with folic acid was applied in nude mice bearing human colon adenocarcinoma. The aim of the study is to see whether folic acid may increase biosynthesis of porphyrins in tumor tissue after systemic or topical administration of ALA or MAL. The production of porphyrins was determined by spectrofluorometric measurements with an optical fibre probe. It was found that the porphyrin production after i.p injection of… Expand
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