The effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of buspirone

  title={The effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of buspirone},
  author={Tommi S. Lamberg and Kari T. Kivistö and Jouko Laitila and K M{\aa}rtensson and Pertti J. Neuvonen},
  journal={European Journal of Clinical Pharmacology},
AbstractObjective: The effects of fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor antidepressant, on the pharmacokinetics and pharmacodynamics of buspirone, a non-benzodiazepine anxiolytic agent, were investigated. Methods: In a randomized, placebo-controlled, two-phase cross-over study, ten healthy volunteers took either 100 mg fluvoxamine or matched placebo orally once daily for 5 days. On day 6, 10 mg buspirone was taken orally. Plasma concentrations of buspirone and its active… 

Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone

Deramciclane does not inhibit CYP3A4 activity as measured by buspirone pharmacokinetics, and there were no indications of relevant pharmacodynamic interaction after multiple doses of deramcIClane and a single dose of buspir one.

The Influence of Fluvoxamine Administration on Glibenclamide Pharmacokinetics After Multiple Oral Dosing in Rats

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In vivo pharmacogenetic studies have indicated that the metabolism and disposition of haloperidol may be regulated by genetically determined polymorphic CYP2D6 activity, however, these findings appear to contradict those from studies in vitro with human liver microsomes and from studies of drug interactions in vivo.

A drug–drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors

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Pharmacokinetic interaction between tandospirone and fluvoxamine in the rat contextual conditioned fear stress model and its functional consequence: Involvement of cytochrome P450 3A4

The pharmacokinetic interaction between tandospirone and fluvoxamine is clarified and their combined effect in the rat anxiety model is evaluated.

Hypnotics and sedatives

Selective serotonin reuptake inhibitor drug interactions in patients receiving statins.

  • C. Andrade
  • Medicine, Biology
    The Journal of clinical psychiatry
  • 2014
Elderly patients commonly receive statin drugs for the primary or secondary prevention of cardiovascular and cerebrovascular events and SSRIs for the treatment of depression, anxiety, or other conditions, and a detailed literature review of statin metabolism and of SSRI effects on CYP enzymes suggests that escitalopram, citaloprams, and paroxetine are almost certain to be safe with all statins.



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The blunting of GH and psychological responses suggest that 5-HT1A receptor function is reduced by chronic fluvoxamine treatment, which is likely to be due to inhibition of first pass liver metabolism by fluv oxamine acting on the cytochrome P-450 system.

A Study of Pharmacokinetic Interaction Between Buspirone and Alprazolam at Steady State

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Metabolism and disposition of buspirone.

Metabolism of the antianxiety drug buspirone in human subjects.

The metabolism of an oral dose of the antianxiety drug buspirone labeled with 14C/15N was studied in human subjects to facilitate structural characterization of the metabolites by mass spectrometry.

Fluvoxamine is a potent inhibitor of cytochrome P4501A2.

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Clinical symptoms were infrequent and varied widely; no symptom clusters were identified; those agents metabolised by cytochrome P450 1A2 isoenzyme appear most likely to be involved in drug-drug interactions with fluvoxamine.

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Clinical evidence is provided suggesting that buspirone augmentation may be a useful clinical alternative in depressed patients who fail to respond to a serotonin reuptake inhibitor.

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