The effect of fluticasone furoate/umeclidinium in adult patients with asthma: a randomized, dose-ranging study.

@article{Lee2015TheEO,
  title={The effect of fluticasone furoate/umeclidinium in adult patients with asthma: a randomized, dose-ranging study.},
  author={Laurie A Lee and Shuying Yang and Edward M. Kerwin and Roopa Trivedi and Lisa D. Edwards and Steven J Pascoe},
  journal={Respiratory medicine},
  year={2015},
  volume={109 1},
  pages={54-62}
}
BACKGROUND We evaluated the dose-response of umeclidinium (UMEC; a long-acting muscarinic antagonist) combined with fluticasone furoate (FF; an inhaled corticosteroid [ICS]) in patients with asthma. METHODS In a double-blind, three-period crossover study, 421 subjects (symptomatic on ICS), were randomized to a sequence of three of seven treatments: FF 100 mcg alone, FF 100 mcg combined with UMEC (15.6, 31.25, 62.5, 125, or 250 mcg), or vilanterol 25 mcg (a long-acting β-agonist), inhaled once… CONTINUE READING
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