The effect of flaxseed supplementation on body weight and body composition: a systematic review and meta‐analysis of 45 randomized placebo‐controlled trials

@article{MohammadiSartang2017TheEO,
  title={The effect of flaxseed supplementation on body weight and body composition: a systematic review and meta‐analysis of 45 randomized placebo‐controlled trials},
  author={Mohsen Mohammadi-Sartang and Zohreh Mazloom and Hamidreza Raeisi-Dehkordi and Reza Barati-Boldaji and Nick Bellissimo and Julia O. Totosy de Zepetnek},
  journal={Obesity Reviews},
  year={2017},
  volume={18},
  pages={1096 - 1107}
}
Flaxseed consumption may be inversely associated with obesity; however, findings of available randomized controlled trials (RCTs) are conflicting. The present study aimed to systematically review and analyse RCTs assessing the effects of flaxseed consumption on body weight and body composition. PubMed, Medline via Ovid, SCOPUS, EMBASE and ISI Web of Sciences databases were searched up to November 2016. Mean changes in body composition indices including body weight, body mass index (BMI) and… 

The effects of chitosan supplementation on body weight and body composition: a systematic review and meta-analysis of randomized controlled trials

TLDR
Evidence is provided that chitosan consumption might be a useful adjunctive pharmacological therapeutic tool for body weight management particularly in overweight/obese participants and well-constructed clinical trials that target body weight and body composition as their primary outcomes are needed.

Does pomegranate consumption affect weight and body composition? A systematic review and meta‐analysis of randomized controlled clinical trials

TLDR
There was no significant effect of pomegranate consumption on weight and body composition indices and electronic databases such as PubMed, Scopus, ISI Web of Science, and Google Scholar were systematically searched for controlled clinical trials assessing the effect.

The Effect of Canola Oil on Body Weight and Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

TLDR
Although CO consumption results in a modest decrease in BW, no significant effect was observed on other adiposity indexes and further well-constructed clinical trials that target BW and body composition as their primary outcomes are needed.

Impact of flaxseed supplementation on plasma lipoprotein(a) concentrations: A systematic review and meta‐analysis of randomized controlled trials

TLDR
It is shown that flaxseed supplementation might significantly decrease plasma Lp(a) levels, and future well‐designed and long‐term clinical trials are required to confirm these results.

The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials.

TLDR
It is revealed that flaxseed oil consumption has favorable effects on SBP in patients with metabolic syndrome and related disorders, however, further investigations are needed to provide more reliable evidence.

The Effects of Flaxseed on Weight Loss in Women with Polycystic Ovarian Syndrome: a Randomized Controlled Trial

TLDR
It is shown that flaxseed supplementation could reduce BMI and weight but other factors did not change significantly and further studies are needed to show thatFlaxseed can be used as a supplement for weight loss in PCOS.

The Effect of Flaxseed Oil Supplementation on Body Composition and Inflammation Indices in Overweight Adults With Pre-Diabetes

TLDR
It showed that flaxseed oil supplementation cannot improve body composition and inflammation.

References

SHOWING 1-10 OF 95 REFERENCES

Meta-analysis of the effects of flaxseed interventions on blood lipids.

TLDR
Flaxseed significantly reduced circulating total and LDL-cholesterol concentrations, but the changes were dependent on the type of intervention, sex, and initial lipid profiles of the subjects.

Flaxseed Supplementation in Metabolic Syndrome Management: A Pilot Randomized, Open‐labeled, Controlled Study

TLDR
It is indicated that co‐administration of flaxseed with lifestyle modification is more effective than lifestyle modification alone in management of MetS; whether these effects will be sustained with longer treatment durations remains to be determined.

The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial.

TLDR
It is suggested that 1-yr incorporation of flaxseed into the diet produced a favorable, but not clinically significant, effect on blood cholesterol and caused no significant change in BMD or symptoms in healthy menopausal women.

Low dose Flaxseed Oil Supplementation Alters the Fatty Acids Profile and the Progression of Metabolic Syndrome in Men without Adequate Medical Treatment

TLDR
In conclusion, low daily doses of flaxseed oil may improve clinical and metabolic parameters in middle-aged men without adequate treatment for metabolic syndrome.

Impact of weight loss diet associated with flaxseed on inflammatory markers in men with cardiovascular risk factors: a clinical study

TLDR
This study suggests that flaxseed added to a weight loss diet could be an important nutritional strategy to reduce inflammation markers such as CRP and TNF-α.

Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study

TLDR
In conclusion, flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.

Effects of a Flaxseed-Derived Lignan Supplement in Type 2 Diabetic Patients: A Randomized, Double-Blind, Cross-Over Trial

TLDR
Daily lignan supplementation resulted in modest, yet statistically significant improvements in glycemic control in type 2 diabetic patients without apparently affecting fasting glucose, lipid profiles and insulin sensitivity.

Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study

TLDR
This study indicates that the FO, which is a rich source of ALA, leads to lower sd-LDL cholesterol concentrations.

Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and progestin activity: a controlled crossover trial.

TLDR
It is indicated that partially defatted flaxseed is effective in lowering LDL cholesterol and no effects on lipoprotein ratios, ex vivo serum androgen or progestin activity, or protein carbonyl content were observed.
...