The effect of fatty acids on the regulation of pyruvate dehydrogenase in perfused rat liver.

@article{Scholz1978TheEO,
  title={The effect of fatty acids on the regulation of pyruvate dehydrogenase in perfused rat liver.},
  author={Roland Scholz and Merle S. Olson and Andreas J. Schwab and Ulrich Schwabe and C W Noell and Werner Braun},
  journal={European journal of biochemistry},
  year={1978},
  volume={86 2},
  pages={519-30}
}
The effect of fatty acids on the rate of pyruvate decarboxylation was studied in perfused livers from fed rats. The production of 14CO2 from infused [1-14C]pyruvate was employed as a monitor of the flux through the pyruvate dehydrogenase reaction. A correction for other decarboxylation reactions was made using kinetic analyses. Fatty acid (octanoate or oleate) infusion caused a stimulation of pyruvate decarboxylation at pyruvate concentrations in the perfusate below 1 mM (up to 3-fold at 0.05… CONTINUE READING

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