The effect of extracellular matrix components on the preservation of human islet function in vitro.

@article{Daoud2010TheEO,
  title={The effect of extracellular matrix components on the preservation of human islet function in vitro.},
  author={Jamal T Daoud and Maria S Petropavlovskaia and Lawrence Rosenberg and Maryam Tabrizian},
  journal={Biomaterials},
  year={2010},
  volume={31 7},
  pages={1676-82}
}
Human islet isolation leads to the loss of the ECM basement membrane which contributes to eventual apoptosis in vitro. The reestablishment of this environment is vital in understanding the mechanism of islet interaction with its surroundings in order to arrive at conditions favourable to islet culture in vitro. In this study, we investigated the effects of the main ECM components collagen I and IV, fibronectin, and laminin on human islet adhesion, survival, and functionality. Results have… CONTINUE READING

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