The effect of exposure duration on the blood level of glucose pyruvate and lactate in acute carbon monoxide intoxication in man

  title={The effect of exposure duration on the blood level of glucose pyruvate and lactate in acute carbon monoxide intoxication in man},
  author={Jerzy A. Sokal},
  journal={Journal of Applied Toxicology},
  • J. Sokal
  • Published 1 December 1985
  • Chemistry, Medicine
  • Journal of Applied Toxicology
Blood glucose, pyruvate and lactate were examined during hospitalization of 13 cases of acute carbon monoxide poisoning developing from short (≦ 1.5 h) or long (10–14 h) exposure. CO intoxication resulted in increased blood levels of all carbohydrate metabolites studied. Increased levels of pyruvate and lactate were much more pronounced and lasted for a longer time following long, compared with short, CO exposure despite similar blood COHb level (about 40% at the beginning of hospitalization). 
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Effect of different conditions of acute exposure to carbon monoxide on the cerebral high-energy phosphates and ultrastructure of brain mitochondria in rats.
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An attempt will be made to describe the characteristic features of hypoxic hypoxia, both at normal and at reduced perfusion pressures, as well as of incomplete and complete ischemia, and to discuss how the metabolic changes relate to irreversible neuronal damage.
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