• Medicine
• Published in
  Journal of cachexia…
  2012
• DOI:10.1007/s13539-011-0047-1

The effect of exercise on IL-6-induced cachexia in the ApcMin/+ mouse

@inproceedings{Puppa2012TheEO,
  title={The effect of exercise on IL-6-induced cachexia in the ApcMin/+ mouse},
  author={Melissa J. Puppa and James P. White and Kandy T. Vel{\'a}zquez and Kristen A. Baltgalvis and Shuichi Sato and John W. Baynes and James A Carson},
  booktitle={Journal of cachexia, sarcopenia and muscle},
  year={2012}
}

• Melissa J. Puppa, James P. White, +4 authors James A Carson

BackgroundCachexia involves unintentional body weight loss including diminished muscle and adipose tissue mass and is associated with an underlying disease. Systemic overexpression of IL-6 accelerates cachexia in the ApcMin/+ mouse, but does not induce wasting in control C57BL/6 mice. With many chronic diseases, chronic inflammation and metabolic dysfunction can be improved with moderate exercise. A direct effect of regular moderate exercise on the prevention of IL-6-induced cachexia in the… CONTINUE READING

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