The effect of ethylene exposure on ethylene oxide in blood and on hepatic cytochrome p450 in Fischer rats.

@article{Fennell2004TheEO,
  title={The effect of ethylene exposure on ethylene oxide in blood and on hepatic cytochrome p450 in Fischer rats.},
  author={Timothy R. Fennell and R. Ross G. Ruf P. Safar W. Schlote F. J. Schuier J. V Snyder and Carl U. Parkinson and John H. Murphy and R. Arden James},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={81 1},
  pages={7-13}
}
Ethylene (74-85-1) is an important petrochemical and is produced endogenously. It is metabolized to ethylene oxide (EO) by cytochrome P450. We studied the inhibition of cytochrome P450 activity during exposure to ethylene, and verified that this inhibition was reflected in the concentration of EO in the blood. Male F344 rats were exposed to 1000, 600, and 300 ppm ethylene by nose-only inhalation for up to 6 h. Blood samples were obtained during exposure. On exposure to 600 ppm ethylene, blood… CONTINUE READING

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