The effect of ethanol on the plasma membrane calcium pump is isoform-specific.

@article{Cervino1998TheEO,
  title={The effect of ethanol on the plasma membrane calcium pump is isoform-specific.},
  author={Vincenza Cervino and Gustavo Benaim and Ernesto Carafoli and Danilo Guerini},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 45},
  pages={
          29811-5
        }
}
The effect of ethanol has been studied on four different isoforms of the plasma membrane Ca2+-ATPase expressed in Sf9 cells with the help of the baculovirus system. The PMCA2CI protein was maximally activated by 0.5% ethanol, a concentration 8-10 times lower than that needed to obtain the same effect on the PMCA4 protein or on the pump of erythrocyte membranes, which is a mixture of isoforms 1 and 4. Experiments performed with truncated pumps indicated that the stimulation by ethanol was lost… CONTINUE READING