The effect of ethanol administration on the disposition and elimination of chlormethiazole

  title={The effect of ethanol administration on the disposition and elimination of chlormethiazole},
  author={R. Bury and P. Desmond and M. L. Mashford and B. Westwood and G. Shaw and K. Breen},
  journal={European Journal of Clinical Pharmacology},
  • R. Bury, P. Desmond, +3 authors K. Breen
  • Published 2004
  • Medicine
  • European Journal of Clinical Pharmacology
  • SummaryAcutely administered ethanol has been shown to inhibit the hepatic metabolism of a number of drugs. Ethanol might be expected to decrease the first-pass extraction of chlormethiazole leading to higher blood levels of this high clearance sedative frequently used in the management of alcoholic patients. Chlormethiazole has a narrow therapeutic index and the unexpected deaths reported in alcoholics taking this drug may have been due to an effect of ethanol on the metabolism of… CONTINUE READING
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