The effect of ethanol administration on the disposition and elimination of chlormethiazole

@article{Bury2004TheEO,
  title={The effect of ethanol administration on the disposition and elimination of chlormethiazole},
  author={R. Bury and P. Desmond and M. L. Mashford and B. Westwood and G. Shaw and K. Breen},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={24},
  pages={383-385}
}
  • R. Bury, P. Desmond, +3 authors K. Breen
  • Published 2004
  • Medicine
  • European Journal of Clinical Pharmacology
  • SummaryAcutely administered ethanol has been shown to inhibit the hepatic metabolism of a number of drugs. Ethanol might be expected to decrease the first-pass extraction of chlormethiazole leading to higher blood levels of this high clearance sedative frequently used in the management of alcoholic patients. Chlormethiazole has a narrow therapeutic index and the unexpected deaths reported in alcoholics taking this drug may have been due to an effect of ethanol on the metabolism of… CONTINUE READING
    5 Citations

    References

    SHOWING 1-10 OF 12 REFERENCES
    Cimetidine impairs the elimination of chlormethiazole
    • 17
    Inhibition of drug metabolism by acute ethanol intoxication. A hepatic microsomal mechanism.
    • 194
    Drug Kinetics and Alcohol Ingestion
    • 107
    Short-term ethanol administration impairs the elimination of chlordiazepoxide (Librium®) in man
    • 26
    A physiological approach to hepatic drug clearance
    • 1,780
    Fatal chlormethiazole poisoning in chronic alcoholics.
    • 33
    A comparison of the effects of general and spinal anaesthesia on chlormethiazole kinetics in the chronically catheterized sheep
    • Clin Exp Pharmacol Physiol
    • 1982
    Effect of ethanol on the pharmacokinetics of chlormethiazole in humans
    • Int J Clin Pharmacol Ther Toxicol
    • 1981
    Mechanism of ethanol-diazepam pharmacokinetic interaction
    • Clin Pharmacol Ther
    • 1980